Cortisol, an important endogenous glucocorticoid in human, regulates various physiologic processes including metabolism, circadian rhythm, and immunity. Glucocorticoids mediate the flight or fight response to stress, but simultaneously suppress numerous immune functions. On the contrary, the androgenic adrenal steroid hormone, dehydroepiandrosterone sulfate (DHEAS), primarily enhances immunity and has anti-glucocorticoid effects [1]. The cortisol/DHEAS ratio (CDR), a simultaneous evaluation of t
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