Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death.

Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial ...

Mouse and human data suggest endothelial ALOX15 and its lipids may help turn some lung clots into protection in sepsis lung injury, highlighting future therapeutic opportunities.

A new preclinical study shows that moderate blood clotting in the lungs may actually help protect against sepsis-related ...

The APT-Sepsis program significantly reduced infection-related outcomes in maternal care, demonstrating the impact of ...

The trial assessed APT-Sepsis implementation in 59 hospitals across Malawi and Uganda, involving a staggering 431,394 women ...

Tumors trigger T-cell exhaustion through a TSP-1–CD47 signaling pathway. Blocking it can restore immune strength and improve cancer treatment.

Researchers have proposed a personalised, multi-target therapeutic approach to treat sepsis by dynamically regulating key signalling pathways that control immune activation, inflammation and cellular ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

(The Center Square) – The Trump administration’s deportation agenda has caused a wide variety of responses across the country. Protests in Portland, Los Angeles and Chicago have prompted calls for ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

Background: Sepsis-induced cardiomyopathy (SICM) is a major cause of high morbidity and mortality in septic patients. In SICM, macrophage infiltration and aberrant immune activation play a critical ...