Mouse and human data suggest endothelial ALOX15 and its lipids may help turn some lung clots into protection in sepsis lung injury, highlighting future therapeutic opportunities.

A new preclinical study shows that moderate blood clotting in the lungs may actually help protect against sepsis-related ...

The APT-Sepsis program significantly reduced infection-related outcomes in maternal care, demonstrating the impact of ...

The trial assessed APT-Sepsis implementation in 59 hospitals across Malawi and Uganda, involving a staggering 431,394 women ...

Tumors trigger T-cell exhaustion through a TSP-1–CD47 signaling pathway. Blocking it can restore immune strength and improve cancer treatment.

Researchers have proposed a personalised, multi-target therapeutic approach to treat sepsis by dynamically regulating key signalling pathways that control immune activation, inflammation and cellular ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

Background: Sepsis-induced cardiomyopathy (SICM) is a major cause of high morbidity and mortality in septic patients. In SICM, macrophage infiltration and aberrant immune activation play a critical ...

Abstract Sepsis is a life-threatening organ dysfunction with a high incidence rate and mortality. The aim of this study was to investigate monocyte-related signaling pathways and hub genes in sepsis ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...