The Indianapolis Colts, led by quarterback Daniel Jones, face the Kansas City Chiefs, led by quarterback Patrick Mahomes, on Sunday, Nov. 23, 2025 at Arrowhead Stadium in Kansas City, Mo.

The Kansas City Chiefs and Indianapolis Colts are set to face off in an epic Week 12 matchup at Arrowhead Stadium that could have major implications on the AFC playoff picture.

According to a report from NFL Insider Jordan Schultz, the Chiefs are signing running back Dameon Pierce to the practice squad.