Spliceosomal introns are noncoding DNA sequences located between exons in many eukaryotic protein-coding genes. Most are removed post-transcriptionally by RNA splicing and do not encode proteins, but ...

Although the participation of spliceosomes is almost always required for intron removal, a few types of genes have self-splicing RNA introns. The RNA transcript of such a gene can carry out the entire ...

A genome-wide study identifies 9,814 poison exons in the human genome and shows that hundreds are brain-specific, linking their mis-splicing to neurological disorders such as Leigh syndrome.

While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines. Her task ...

Researchers at the University of Oslo have mapped which parts of our DNA carry the inherited differences behind complex traits and disorders. The more complex the trait, the more of those differences ...

Schizophrenia, height, cholesterol. Each has its own genetic signature. That signature is made up of genetic variants: small differences in the DNA sequence that make one person's genome differ from ...

An Arabidopsis loss-of-function study links the mitochondrial PPR9 protein to impaired RNA splicing, defective respiratory complex I assembly and arrested early embryonic development.