Bilirubin, a by-product of haem metabolism, plays a crucial role in human physiology beyond its well-known association with jaundice. Emerging evidence underscores its antioxidant and cell signalling ...

Patients with the Crigler–Najjar syndrome lack the enzyme uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the absence of which leads to severe unconjugated hyperbilirubinemia that ...

Background: Extensive laboratory investigations are routinely performed to exclude rare but potentially catastrophic causes of prolonged jaundice. Aims: This study aims to review the investigations ...

Crigler-Najjar syndrome (CNS) and Gilbert syndrome (GS) are rare autosomal recessive disorders causing unconjugated hyperbilirubinemia due to reduced ...

A favorite intellectual exercise of those interested in bile pigments and their metabolism is the devising of an all-purpose classification of jaundice. The object of the game is to create a scheme ...

Cholecystitis, or gallbladder inflammation, can sometimes cause jaundice if something blocks the flow of bile from the gallbladder. Cholecystitis refers to inflammation of the gallbladder. There are ...