Disrupting the production of a class of lipids known as sphingolipids in neurons improved symptoms of neurodegeneration and increased survival in a mouse model, according to new research led by the ...

Sphingolipid biosynthesis in pathogenic fungi is a multistep pathway that begins with the condensation of serine and a long-chain acyl‐CoA by serine palmitoyltransferase, producing a 3-keto ...

A team of researchers has linked neuronal activity to the levels of sphingolipids, a type of fat, in brain cells. Furthermore, disruption of sphingolipid metabolism led to significant neuronal damage ...

A phase 2 study of intravenous pembrolizumab and intratumorally injected autologous dendritic cells (DCs) in refractory colorectal cancer (CRC). This is an ASCO Meeting Abstract from the 2025 ASCO ...