Get the full 49ers Week 10 practice and media schedule ahead of their matchup vs. the Rams, including press conferences and practice times.

NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Los Angeles Rams and San Francisco 49ers.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

There are plenty of exciting matchups on the Week 10 NFL schedule, including the Los Angeles Rams squaring off against the San Francisco 49ers. To gain an edge prior to Week 10 in the NFL, read our betting preview below.

They will head out on the road to face off against the Arizona Cardinals at 4:05 p.m. ET at State Farm Stadium. The 49ers will be looking to extend their current five-game winning streak. Last Sunday,

Despite their records, the Cardinals have a better point differential than the 49ers. Arizona has scored 180 and allowed 171, while San Francisco has scored 194 and allowed 188. The 49ers have played in one more game though so here’s how that breaks down:

The San Francisco 49ers visit the New York Giants in Week 9 of the NFL regular season. Here's the start time and where to watch.

Week 9 vs. Giants with three full practices and media sessions featuring Kyle Shanahan, Robert Saleh, and Klay Kubiak.

Sunday in Tampa, division leaders and MVP contenders square off when Baker Mayfield and the Buccaneers (6-2) host Drake Maye and the New England Patriots (7-2). The NFC South-leading Buccaneers are coming off their bye week and are slight home favorites (-2.