Endocytosis is the process by which cells take in molecules from their surroundings. Clathrin-dependent endocytosis requires the recruitment of clathrin to help curve the plasma membrane into the ...

Figure 1: Oncogenic KRAS-expressing pancreatic cancer cells display increased levels of macropinocytosis both in culture and in vivo. Figure 2: Oncogenic Kras-induced macropinocytosis in mouse NIH 3T3 ...

The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of particulate matter ...

In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic ...

Philosophical Transactions: Biological Sciences, Vol. 374, No. 1765, Theo Murphy meeting issue: Macropinocytosis (4 February 2019), pp. 1-10 (10 pages) ...

Two recent studies have independently identified macropinocytosis, a nutrient procurement pathway whereby cancer cells take up extracellular fluid droplets containing proteins and other macromolecules ...

Scientists have demonstrated that blocking 'cell drinking,' or macropinocytosis, in the thick tissue surrounding a pancreatic tumor slowed tumor growth--providing more evidence that macropinocytosis ...

Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging 'fuel' through an alternative supply route, called macropinocytosis. Blocking this process, often described as 'cellular ...

BIRMINGHAM, Ala. - In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- ...