As stem cells decide who they want to become, they embark on a journey of gradual differentiation into their final cell fate. This transformation is traditionally depicted by the Waddington landscape ...

The scientists showed they could precisely interrupt the flow of the differentiation process, thereby enhancing antitumor efficacy. "T cells are the cornerstone of tumor immunotherapy, and we found a ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

(L to R) Co-first authors Peipei Zhou, Ph.D., Hao Shi, Ph.D. and corresponding author Hongbo Chi, Ph.D., all of the St. Jude Department of Immunology. T cells are used in adoptive cell therapy (ACT) ...