Cortical interneurons (InNs) are primarily derived from the ganglionic eminences (GEs) via the tangential migration process and play a crucial role in the development of the central nervous system 1,2 ...

Cathepsin B (CatB), a protease in endosomal and lysosomal compartments, plays a key role in neuronal protein processing and degradation, but its function in brain development remains unclear. In this ...

A new study finds key differences in the development of the cortex between autistic boys and girls ages 2-13. The study found sex-specific changes in the thickness of the outer layer of the brain, ...

Past neuroscience studies have consistently highlighted the profound changes that the human brain undergoes throughout childhood and adolescence. These efforts have uncovered various stages of ...

Glutamine synthetase(GS) acts as a key regular of postnatal brain development, integrating metabolic control via the mTOR pathway to coordinate cell-specific gene expression, protein synthesis,and ...

Perhaps our most defining characteristic as a species, the six-layered human cortex, hosts billions of neural connections that bestow Homo sapiens with higher-order thinking. But how does this ...

Combining microscopy, scanning, and deep learning enables more precise imaging of functional dynamics in neural networks of human cortical organoids.

The outer regions of the brain, the cortex, have specific layers of different cells—neurons—that are similarly ordered among all mammals, from tiny mouse brains to huge elephant brains. However, the ...

This image shows densely accumulated dendritic spines. Researchers from Kyushu University discovered a previously unrecognized synaptic “hotspot” that forms during adolescence, challenging the ...

A new study led by UC Davis researchers finds widespread differences in brain development between autistic boys and girls ages 2–13. The study, published recently in Molecular Psychiatry, found ...