Increased CD4+ and CD8+ T-cell density in salivary gland tissue is evident in patients with Sjögren syndrome prior to ...
The ability of immune cells—particularly CD8 + T cells—to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies. However, the factors and ...
BI-1808 monotherapy demonstrated an excellent safety profile and evidence of single-agent anti-tumor activity, correlating ...
A mouse study reveals how aging immune cells may impair memory outside the brain, showing that blocking CD8+ T cell activity or their secreted factor, granzyme K, helped restore cognitive performance ...
A new EMBO Reports study shows that the kinase Lck phosphorylates the autophagy receptor p62 at tyrosine 433 within minutes ...
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...
In paired biopsies with detectable post-treatment tumor (n=98), aglatimagene increased the intratumoral lymphocyte fraction (p=0.002) and lymphocyte–tumor enrichment and mixing scores (both p<0.001) ...