St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with ...
BI-1808 monotherapy demonstrated an excellent safety profile and evidence of single-agent anti-tumor activity, correlating ...
The ability of immune cells—particularly CD8 + T cells—to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies. However, the factors and ...
A new study shows that activating the lipid sensor PPARδ in immune cells rather than cancer cells flips the metabolic ...
A mouse study reveals how aging immune cells may impair memory outside the brain, showing that blocking CD8+ T cell activity or their secreted factor, granzyme K, helped restore cognitive performance ...
A new review highlights the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway as a central switch ...
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...
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