Christian McCaffrey and the San Francisco 49ers face Shedeur Sanders and the Cleveland Browns in Week 13 of the NFL season.

Trevor Lawrence and the Jacksonville Jaguars face Cam Ward and the Tennessee Titans in Week 13 of the NFL season on Sunday.

Ashton Jeanty and the Las Vegas Raiders face Justin Herbert and the Los Angeles Chargers in Week 13 of the NFL season on Sunday.

C.J. Stroud and the Houston Texans face Jonathan Taylor and the Indianapolis Colts in Week 13 of the NFL season on Sunday.

Josh Allen and the Buffalo Bills face Aaron Rodgers and the Pittsburgh Steelers in Week 13 of the NFL season on Sunday.

Justin Jefferson and the Minnesota Vikings face Sam Darnold and the Seattle Seahawks in Week 13 of the NFL season on Sunday ...

Trey McBride and the Arizona Cardinals face Baker Mayfield and the Tampa Bay Buccaneers in Week 13 of the NFL season on Sunday.

Patrick Mahomes and the Kansas City Chiefs take on Dak Prescott and the Dallas Cowboys in a Thanksgiving Day NFL matchup.

Kirk Cousins and the Atlanta Falcons face Breece Hall and the New York Jets in Week 13 of the NFL season on Sunday.

Bo Nix and the Denver Broncos face Marcus Mariota and the Washington Commanders in this NFL matchup on Sunday Night Football.

The holiday football games kickoff at 1 P.M. ET on Thanksgiving.

Micah Parsons and the Green Bay Packers take on Jahmyr Gibbs and the Detroit Lions in a classic Thanksgiving Day NFL matchup.