To attach probes for imaging to biomolecules inside cells or organisms, chemists have developed so-called bioorthogonal reactions that don’t interfere with the biochemistry of the living things.

Coined by Carolyn Bertozzi who won the 2022 Nobel prize for click chemistry, ‘bioorthogonal click chemistry’ encompasses a class of click reactions that are both fast and biologically inert, making ...

Please provide your email address to receive an email when new articles are posted on . It’s not often that a 2 a.m. phone call marks the highlight of someone’s career. That call notified Bertozzi, ...

The 2022 Nobel Prize in Chemistry was awarded to Carolyn Bertozzi, Morten Meldal and K. Barry Sharpless for their development of click and bioorthogonal chemistry which are used by chemists around the ...

The functional groups participating in the reaction are inert to biologically active molecules, and reactive selectively with each other. The chemistry of the reaction must also be nontoxic to the ...

Bioorthogonal chemical reporters are small exogenous reporters which do not chemically modify the biomolecules they are tagged to. Their small size means they do not interfere with gene expression or ...

The 2022 Nobel Prize in chemistry was awarded to scientists Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for their development of click chemistry and bioorthogonal chemistry. These ...

Bioorthogonal chemistry has revolutionised our ability to see the invisible by capturing the fleeting molecular events that sustain life. From single-molecule tracking to whole-organism imaging, ...