A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. AD, a representative form of senile dementia, occurs ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...

Study shows how cells employ a universal strategy, reliant on TRIM21, to redirect its autophagy machinery to any harmful material tagged with antibodies.

Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the precise mechanisms by which autophagy maintains brain health have remained ...

In a recent study published in the journal Neuron, researchers at the University of Cambridge and Newcastle University, UK, examined the relationship between autophagy, aging, and neurodegeneration.

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, ...

A new study reveals that age-related autophagy decline blocks embryo development by triggering a lipid-burning crisis.

Downy mildew is a persistent threat to Brassica vegetable production, but the molecular triggers that help plants resist this ...