When German psychiatrist Alois Alzheimer made the post-mortem discovery of amyloid plaques and neurofibrillary tangles in the early 1900s, he birthed the discovery of a cruel and insidious disorder.
More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as "lipoid granules," along with the buildup of amyloid‐beta (amyloid) plaques and tau protein tangles.