The New England Patriots have a chance to clinch the AFC East this weekend when they face the Buffalo Bills in Week 15 action. The Patriots upset the Bills in

The Pats' defense ranks Top 10 in many metrics. They are especially stout against the run, which could challenge the Bills and specifically, running back James Cook. The Bills' bell cow back is the NFL's second-leading rusher with 1,308yds (trails only Jonathan Taylor (1,356yds).

Our Giants vs. Patriots predictions believe New England will be all business from the opening gun. Free MNF Week 13 picks for December 1, 2025.

As of Sunday morning, the Bills are 1.5-point favorites over the Patriots entering the Week 15 matchup, per FanDuel. It’s the second time this season the Bills have entered a matchup vs. their rival as favorites, including in Week 5, when Buffalo was favored by 7.5 points over the Patriots.

New users can sign up to wager on NFL action with the DraftKings promo code and bet $5 to get $200 in bonus bets (if you win). Buffalo Bills: James Cook - Rushing Yards Under 79.5 (-112) New England Patriots: Stefon Diggs - Receiving Yards Over 52.

The Buffalo Bills' win over the New England Patriots in Week 15 added extra intrigue to the AFC East standings and race for the division crown.