The San Francisco 49ers are at a crossroads with a massive division game that may determine if they are contenders or pretenders. The team is going to need big performances from a few key starters if they want to walk out of Arizona with a sweep of their division rivals.

Injuries and veteran leadership clash as key defenders aim to dominate this crucial NFC West showdown. Keep your eyes on these defensive standouts.

The Arizona Cardinals have a lengthy injury report ahead of Week 11, with seven players officially ruled out against the San Francisco 49ers.

For the Cardinals, all of Marvin Harrison Jr. (illness), Will Johnson (back/hip), Dadrion Taylor-Demerson (ankle), Jonah Williams (shoulder), Mack Wilson (ribs), Baron Browning (concussion) and Hayden Conner (knee) are out.

The Arizona Cardinals were destroyed by the Seahawks last week but they have a chance to get back on track in Week 11, with the 49ers coming to town.

The Arizona Cardinals thankfully concluded their practice week on Friday in preparation for Sunday’s game against the San Francisco 49ers. Afterward, the team distributed a massive injury report that lists seven players out and six questionable.

The San Francisco 49ers, the Arizona Cardinals ' Week 11 opponent, get their starting quarterback back. Quarterback Brock Purdy will return to the starting lineup, playing for the first time since Week 5. Head coach Kyle Shanahan announced that Purdy would start on Sunday in the taping of the 49ers "Game Plan" television program.

The San Francisco 49ers are expecting the return of QB Brock Purdy as they try to make a playoff push in the NFC West.

When these two faced back in Week 3, it was 49ers’ backup quarterback Mac Jones outlasting the Cardinals’ starting quarterback Kyler Murray in a 16-15 San Francisco victory. The roles will be reversed as Brock Purdy will make his first start since Week 4 against Jacoby Brissett, who will be making his fifth start since replacing the injured Murray.