Purdy returns as the starter Sunday when the 49ers (6-4) visit the Arizona Cardinals (3-6) at State Farm Stadium (Fox, 1:05 p.m.). He’s missed the last six games with turf toe and two others before that, during which time the 49ers were 5-3. You’d be hard-pressed to find much fault with Jones even in the three losses.

The San Francisco 49ers are at a crossroads with a massive division game that may determine if they are contenders or pretenders. The team is going to need big performances from a few key starters if they want to walk out of Arizona with a sweep of their division rivals.

The San Francisco 49ers will meet the Arizona Cardinals on Sunday for the second time this year, but they might be without a starter.

Sunday's showdown in the desert will feature two teams that are coming off tough losses.

The Arizona Cardinals have a lengthy injury report ahead of Week 11, with seven players officially ruled out against the San Francisco 49ers.

Leaders from University of the Pacific and the San Francisco 49ers came together on Friday to announce a multiyear partnership to expand access to higher education.

The San Francisco 49ers' defense took a new hit with the news that cornerback Deommodore Lenoir suffered an injury in practice that might keep him out of Sunday's game against the Cardinals.