Isle is a commune in the Haute-Vienne department in the Nouvelle-Aquitaine region in west-central France. As of 2019, Isle is the fifth co…Isle is a commune in the Haute-Vienne department in the Nouvelle-Aquitaine region in west-central France. As of 2019, Isle is the fifth commune of the department, after Limoges, Saint-Junien, Panazol and Couzeix.